Partner Institute
Narayana Health and NIMHANS
Stroke causes neuro-restoration that remains variable and treatment of stroke-caused infarct and penumbra is challenging. Standard stroke care includes thrombolysis, mechanical thrombectomy, decompressive craniectomy if indicated, and early rehabilitation. In addition to above treatments, novel therapeutic modalities include stem cell therapy, neuromodulation, brain-machine interface, robotic rehabilitation and multimodal treatments. Stem Cell-Based Stroke Management Program includes collaboration between Mazumdar Shaw Medical Foundation (MSMF) and Narayana Institute of Neurosciences, MSMC under Narayana Health (NH), a program for the clinical application of stem cell treatment in stroke survivors.
Aim
To establish, identify markers of plasticity/recovery and modify stem cell treatment protocols to enhance functional recovery with augmentative techniques and assess the effects of these adjuncts on overall patient outcomes.
In last year, Advanced Stroke Monitoring Lab with Functional Transcranial Doppler, Transcranial Magnetic Stimulation (TMS), Functional EEG, Quantitative Motion Analysis, Computerized Cognitive Assessment to be used as an advanced stroke diagnostics facility. TMS and Transcranial Doppler device testing on healthy controls has been initiated. BSL2 Facility has been expanded and functional. cGMP facility has been initiated and is in progress in consultation with a regulatory expert with Standard operating protocols being developed. The project has been divided into 5 phases for stroke, phases 1A to 1C will focus on discerning the effects of hyperbaric oxygen (HBOT), augmented reality, and robotic rehabilitation in different phases of stroke recovery. Phase 2A and 2B will focus on the effects of stem cells and adjuncts on recovery from stroke. The in vitro studies to see effect of HBOT on viability, proliferation, and molecular profile in human astrocytes (HA), glioma cells (U251) are being assessed along with Bone-marrow derived mesenchymal stem cell line (Hs_5) in future. Project milestones achieved are IEC Approval and patient recruitment for the HBOT and robotic rehabilitation trials. Manuscripts under preparation; use of adjunctive hyperbaric oxygen and peripheral magnetic stimulation (device procured from SKAN grant), and functional transcranial Doppler in healthy controls.