Partner Institute
The partner institute for this project is the National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru and Narayan Hospitals (NH).
This is a large cohort study aimed at understanding the natural history of stroke employing a mixed cohort study design (Retrospective-Prospective cohort study). This will be conducted in Mulbagal taluka of Kolara district and select urban wards of Bengaluru city. Sampling strategy has been finalized. The estimated sample size of 2 lakh people aged 30 years and above will be followed up for a period of 4 years as ‘stroke-free cohort’, stratified based on a set of risk factors such as obesity, stress, substance use, and diet/physical activity, other NCDs cohorts amongst the eligible population of ~4 lakh. After the first-ever incidence of stroke among participants, a new cohort named ‘stroke cohort’ will be formed utilizing a prospective cohort study design consisting of an expected case load of ~750 cases over 3 years.
The study also adopts the Quasi Experimental Pre-Post intervention study design to a sample of 255 stroke cases to study the effectiveness of a Comprehensive Acute Stroke CAre moDEl (CASCADE model) developed to improve preparedness, management of stroke, ensuring improved survival, reduced disability, and enhanced quality of life of stroke patients. Monitoring protocol and format has been developed through workshop. Clinical Trial Registry India (CTRI) registration number has been obtained for this study. Specific achievements are Stroke-free, Stroke and Hospital preparedness questionnaire near final, protocols finalized and approved by the Expert advisory group. The approvals of IEC for all the amendments in the protocol were obtained.