Profile Navigation

Biosketch

To understand fundamental mechanisms that safeguard proteome and translatome integrity in neurons and to translate these insights into strategies for early diagnostics in brain disorders like in autism spectrum disorder (ASD).

Research Focus

  • Genetics of Autism Spectrum Disorder
  • Decoding ribosome machinery
  • Epitranscriptome-based Translation regulation

Publications

  1. D’Souza MN, Gowda NKC et al. Altering rRNA 2’O-methylation pattern during neuronal differentiation is regulated by FMRP. RNA Biology (2025). Corresponding Author
  2. Durbagula S et al.. Gowda NKC Genetic insights into male ASD in Indian families. General Psychiatry (2024). Corresponding Author
  3. Gowda NKC et al. NMDARmediated dynamic changes in m⁶A inversely correlate with neuronal translation. Sci Reports (2022).
  4. D’Souza MN, Gowda NKC et al. FMRP interacts with C/D box snoRNA and regulates rRNA methylation. iScience (2018).
  5. Gowda NKC et al. Fes1/HspBP1 mimic substrate to release misfolded proteins from Hsp70. Nature Str Mol Bio (2018).
  6. Gowda NKC et al. Cytosolic splice isoform of Fes1 required for degradation of misfolded proteins in yeast. Mol Biol Cell (2016).
  7. Gowda NKC et al. Hsp70 nucleotide exchange factor Fes1 is essential for ubiquitindependent degradation of misfolded cytosolic proteins. PNAS (2013).

Additional Information

Invited Talk:

Invited talk on “Role of FMRP in translation regulation in human embryonic stem cells and its differentiation”, International Conference on Neurodegeneration: Biomarkers and Therapeutic targets, School of Life Science, JSS, Mysore, India. September 2023

Invited talk on “Exploration of 2’O methylation and FMRP pathways”, International Conference on OPEN Autism, St. John’s Research Institute, Bangalore, India. March 2023

Indian Academy of Neuroscience (IAN) – 4th Satellite Symposium of Annual meeting, Theme: ‘Neuron – Glia Interaction: Recent concepts and Advances’. Dec 2021.

Conference Co-organized:

OPEN Autism – International Conference, CARE-ADD: St. John’s National Academy of Health Science, March 2023 Bangalore, India.

Virtual Guest lecturer on “Molecular Players in Autism and Neurodevelopmental disorder” – Nov 2022, St. John’s Research Institute, Bangalore, India.

Grants

  • Principal Investigator – SERB Start-up Research Grant, 2024 – 2025.
  • SERB International Travel Grant – 2023.
  • Principal Investigator – Awarded SERB-NPDF, India, 2019-2021.
  • Awarded fellowship from Federation of European Biochemical Societies (FEBS) / Young Scientists Forum (YSF), 2013-2014.

Press Releases

Professional Profiles

Collaborations

  • St. John’s Research Institute
  • CBR-IISc
  • DBG-IISc
  • MAHE